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Motsoako oa gallic acid le ho otlolla ho fokotsa matšoao a ho ruruha ha ramatiki liseleng

Re sebelisa li-cookies ho ntlafatsa boiphihlelo ba hau.Ka ho tsoela pele ho sheba sebaka sena sa marang-rang, u lumellana le tšebeliso ea rona ea li-cookies.Lintlha tse ling.
Sehlopha se etelletsoeng pele ke bafuputsi ba Univesithi ea Washington State se sebelisitse gallic acid (antioxidant e fumanoang ka gallnut, tee e tala le limela tse ling) 'me sa sebelisa mokhoa oa ho otlolla li-chondrocyte tsa batho tse nkiloeng mangoleng a ramatiki.Etsisa ho otlolla ho etsahalang ha o tsamaya.Motsoako ona ha o fokotse matšoao a ho ruruha a ramatiki liseleng feela, empa hape o eketsa tlhahiso ea protheine e lakatsehang e fumanehang ka har'a lefufuru le phetseng hantle.
Le hoja e ntse e le mekhahlelo ea pele, liphetho tsa lipatlisiso li bontša hore mokhoa o mocha o ka etsoa ho sebetsana le lisele tsa lefufuru tse nkiloeng ho bakuli ho hōlisa lisele kapa lisele bakeng sa ho kenngoa hape.
Re fumane hore ho otlolla manonyeletso ho tšoana le boikoetliso seleng ka boeona, ho kopantsoe le asiti ea gallic ho fokotsa matšoao a ho ruruha, ho bolelang hore re ka khutlisa lefu la masapo a manonyeletso.Ha e le hantle ho tšoana le boikoetliso bo botle le phepo e nepahetseng maemong a manyane.”
Bakeng sa thuto, e phatlalalitsoeng ho Experimental Cell Research, bafuputsi ba ile ba bokella lisele tsa lefu la masapo a osteoarthritis ho tloha mangole a fanoeng a nkiloeng nakong ea ho buuoa ka kopanelo ho Pullman Regional Hospital.Ba ile ba lema lisele ka laboratoring 'me ba qala ho lekola "liphepa" tse tšeletseng tsa "phepo" kapa lihlahisoa tsa phepo e nepahetseng, ho kenyelletsa le vithamine C, vithamine E le curcumin.Li-antioxidants li ka fokotsa li-radicals tsa mahala, e leng liathomo tse sa tsitsang tse bakoang ke khatello ea oxidative, e ka senyang lisele le lisele.
Liteko tsa laboratori li bontša hore gallic acid ke antioxidant e sebetsang ka ho fetisisa bakeng sa ho fokotsa li-radicals tsa mahala liseleng tsa lefufuru la osteoarthritis.Joale, bafuputsi ba ile ba sebelisa selefouno e entsoeng ke Curi Bio Inc. ho sebelisa gallic acid le ho eketsa ho otlolla.Ba beha ho otlolla ho 5%, boemo bo lumellanang le ho otloloha ha lengole ha motho a tsamaea.
Motsoako ona o fokotsa matšoao a ho ruruha a bitsoang matrix metalloproteinases.E eketsa tlhahiso ea collagen le glycosaminoglycans, metsoako ena e etsa lisele tse hokahaneng ka botšepehi, matla a tsitsitseng le bokhoni ba ho hanela matla a khatello ea boima ba 'mele manonyeletsong.Ho otlolla le gallic acid ho boetse ho ekelitse polelo ea liprotheine tse ling tse peli tse khethehileng tsa lefufuru.
Osteoarthritis ke lefu le atileng haholo la mesifa le masapo lefatšeng.E senya lefufuru le manonyeletso, e baka bohloko le ho thibela motsamao.Hajoale ha ho na pheko e felletseng.Kalafo e fapana ho tloha ho fana ka li-painkillers ho ea ho opereishene ho nkela manonyeletso ka lithethefatsi tsa maiketsetso, empa esita le ho buuoa ha ho lumelle mokuli hore a khutlele ho ikoetlisa ka ho feletseng.
Mokhoa o mong o bitsoa autologous chondrocyte implantation kapa ACI, e kenyelletsang ho tlosa lisele tsa lefufuru lenonyeletsong, ho li hōlisa ho fihlela palo e kholo, ebe o li kenya hape.Bafuputsi ba bontšitse hore hona joale, lisele ha li sebetsanoe pele li kenngoa hape, 'me ho hloka phekolo ho ka etsa hore lisele li hōle li fokola ka fibrocartilage.Ba ka 'na ba boela ba angoa ke lefu la osteoarthritis,' me mekhoa ena e ke ke ea tsosolosa tšebetso e feletseng ho manonyeletso.Phuputso ena e bontša mokhoa o ka khonehang oa ho hlahisa mokhoa o ts'oanang ka ho qala ho sebetsana le li-chondrocyte 'me ka nako e ts'oanang li li hōlisa hore e be lisele tse ka kenngoa hape.
"Re ntse re ntšetsa pele theknoloji ea ho etsa lefufuru le nchafalitsoeng ka laboratoring.Lefufuru lena le ka ’na la kenngoa maqeba a lefufuru, kahoo la fokotsa palo ea ho nkeloa sebaka ha manonyeletso,” ho boletse Bernard W. Wojland, moprofesa Sekolong sa Boenjiniere ba Lik’hemik’hale le Boenjiniere ba Lik’hemik’hale.Ho boletse Bernard Van Wie.Mofuputsi ea ka sehloohong le mongoli ea tsamaisanang le eena."Re batla ho theha lefufuru la tlhaho le sebetsang ka tloaelo ho tloha qalong, ho fapana le ho nkela manonyeletso."
Boithuto bona bo eketsa bopaki ba hore ho ja lijo tse nang le antioxidant le boikoetliso bo ka ba molemo, le hoja bafuputsi ba lemosa hore asiti ea gallic ha ea lokela ho nkoa e le panacea, 'me ketso leha e le efe e lokela ho buisanoa le ngaka ea motho feela.
"Sena se fana ka bopaki ba hore lijo tse nepahetseng le boikoetliso li hlile lia sebetsa," ho boletse Abusharkh.“Esita le ho batho ba nang le ramatiki e bonolo, boikoetliso bo molemo haholo.Lefufuru la rona la lefufuru le mpe haholo ha re paqame kapa re lutse letsatsi lohle;re tlameha ho etsa mesebetsi e itseng.”
Patlisiso ena e ne e tšehelitsoe ka lichelete ke National Science Foundation le National Health Protein Biotechnology Training Institute.
Abu Shak, Ha le ba bang.(2021) Kopanya ho otlolla le gallic acid ho fokotsa index ea ho ruruha le ho khothaletsa tlhahiso ea matrix ea extracellular ho osteoarthritis human articular cartilage cell.Patlisiso ea lisele tsa liteko.doi.org/10.1016/j.yexcr.2021.112841.
Tags: antioxidant, ramatiki, bioengineering, biotechnology, lefufuru, lisele, collagen, lipuisano, curcumin, lijo, ngaka, boikoetliso, radicals mahala, tee e tala, sepetlele, ho ruruha, laboratori, micro, musculoskeletal, bone Arthritis, khatello ea kelello ea oxidative, bohloko, pH, protheine, lipatlisiso, khatello ea kelello, ho buuoa, tee, vithamine C, vithamine E, ho tsamaea
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Nako ea poso: Dec-22-2021